Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention
نویسندگان
چکیده
منابع مشابه
task-based language teaching in iran: a mixed study through constructing and validating a new questionnaire based on theoretical, sociocultural, and educational frameworks
جنبه های گوناگونی از زندگی در ایران را از جمله سبک زندگی، علم و امکانات فنی و تکنولوژیکی می توان کم یا بیش وارداتی در نظر گرفت. زبان انگلیسی و روش تدریس آن نیز از این قاعده مثتسنی نیست. با این حال گاهی سوال پیش می آید که آیا یک روش خاص با زیر ساخت های نظری، فرهنگی اجتماعی و آموزشی جامعه ایرانی سازگاری دارد یا خیر. این تحقیق بر اساس روش های ترکیبی انجام شده است.پرسش نامه ای نیز برای زبان آموزان ...
Computational allosteric ligand binding site identification on Ras proteins.
A number of computational techniques have been proposed to expedite the process of allosteric ligand binding site identification in inherently flexible and hence challenging drug targets. Some of these techniques have been instrumental in the discovery of allosteric ligand binding sites on Ras proteins, a group of elusive anticancer drug targets. This review provides an overview of these techni...
متن کاملA New Criterion for Screening Medical Applicants
Introduction. In the current screening system, new admissions are based on general intelligence as measured by universities entrance examination. Considering the fact that an important function of medical graduates is to educate the patients how to restore and take care of their health, communicative competence and skills would be, at least, as important as general intelligence. To show that la...
متن کاملa new il-2rg gene mutation in an x-linked scid identified through trec/krec screening: a case report
severe combined immunodeficiency (scid) represents a rare group of primary immunodeficiency disorders (pids), with known or unknown genetic alterations. here, we report a new interleukin 2 receptor, gamma chain (il-2rg) mutation in an iranian scid newborn.the patient was a 6-day old boy with a family history of pid. the child was screened using a molecular-based analysis for the assessment of t...
متن کاملA New Peptide Ligand for Targeting Human Carbonic Anhydrase IX, Identified through the Phage Display Technology
UNLABELLED Carbonic anhydrase IX (CAIX) is a transmembrane enzyme found to be overexpressed in various tumors and associated with tumor hypoxia. Ligands binding this target may be used to visualize hypoxia, tumor manifestation or treat tumors by endoradiotherapy. METHODS Phage display was performed with a 12 amino acid phage display library by panning against a recombinant extracellular domai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2021
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.0c01944